About Beeline Medicines:

Beeline Medicines is a clinical‑stage biotechnology company focused on developing and delivering category-leading precision therapies to transform the lives of people living with autoimmune and inflammatory diseases. With a portfolio of potential best-in-class and first-in-disease therapeutic candidates that directly target key pathways governing dysregulated immunological and inflammatory responses, the Company is developing medicines that have the opportunity to provide durable, life-changing impact. Led by an established executive team and backed by world-class life science investors, each day Beeline Medicines is determined to bring the scientific rigor and operational excellence to get to what matters for patients – realizing a world where people with immune-mediated diseases can live life fully.

Job Summary:

The Senior Medical Director, Medical Affairs is a senior therapeutic and disease area expert who serves as the organization's primary external medical and scientific resource for healthcare providers (HCPs), key medical experts (KMEs), clinical investigators, healthcare plans, hospital formulary decision-makers, and patient advocacy organizations. This role operates at the intersection of scientific leadership and external engagement — building and sustaining trusted peer-level relationships within the I&I; community while driving the development and execution of the organization's medical affairs strategy most notably for the Beeline Medicines lead program; an investigational selective, oral, once-daily TLR7/8 inhibitor advancing into pivotal development for systemic and cutaneous lupus erythematosus — and for the broader I&I; portfolio. The Senior Medical Director leads scientific exchange,



supports evidence generation, shapes medical education and KME engagement programs, and serves as a senior internal scientific authority — providing medical input to clinical development, commercial readiness, market access, and regulatory strategy. The Senior Medical Director also serves as a medical reviewer and signatory on the promotional and medical review (MLR) committee for all externally facing company materials for health care professionals, advocacy groups and allied health care functions globally, ensuring factual accuracy and compliance with industry codes of conduct and regulations Reporting to the SVP of Clinical Development and Medical Affairs, this individual brings deep scientific expertise in autoimmune disease, demonstrated KME relationship management, and the strategic leadership presence required to drive the medical affairs function forward in a clinical-stage, resource-efficient biotech environment.

Work Arrangement &

Location:

Hybrid
- This position follows a hybrid work schedule, requiring a minimum of two (2) days in office per week — currently designated as Tuesday and Wednesday. Additional on-site days may be required based on business needs, team priorities, or leadership direction.

Essential Duties and

Responsibilities:

- Serve as the primary medical and scientific point of contact for KMEs,



clinical investigators, HCPs, healthcare plan decision-makers, and patient advocacy groups within the I&I; therapeutic area — with a primary focus on lupus (SLE and CLE) across rheumatology, dermatology, and nephrology — building and sustaining trusted, peer-level relationships that advance the organization's scientific and medical objectives. The Senior Medical Director may also support other therapeutic areas as required.
- Define and lead the execution of the medical affairs strategy for the I&I; pipeline, including lupus indications — encompassing KME engagement, evidence generation, medical education, advisory board programming, and publication strategy — in alignment with clinical development milestones and corporate goals.
- Lead and conduct peer-to-peer scientific exchange with KMEs, investigators, and HCPs — sharing clinical and emerging data, discussing unmet medical needs, and gathering external insights that inform medical strategy, pipeline positioning, and commercial readiness.
- Monitor and critically assess competitive clinical data and emerging mechanisms to inform differentiation and scientific positioning.
- Partner with Scientific Communications to develop and maintain the core scientific narrative, medical communications platform, and scientific lexicon; including unbranded disease-state and mechanism-of-action education to build external scientific understanding of a novel target ahead of pivotal readouts.
- Lead the design and execution of medical advisory board meetings — identifying and engaging the right scientific experts, developing scientifically rigorous agendas, and ensuring that advisory boa

📌 Senior Medical Director, Lupus Medical Affairs (Town of Cambridge)
🏢 Beeline Medicines
📍 Town of Cambridge