Principal Investigator | Clinical Trials

Adelaide, SA

Clinical/Medical Research (Healthcare & Medical)

Full time

About us:

Operating for more than 30 years, CMAX is Australia’s longest running and most experienced clinical trial units conducting successful world-leading research for local and international clients, specialising in a range of early-phase trials and first-in-human studies.

We are proud to be a key contributor in the advancement of global medicines and technologies - from vaccines and pain control to early warning bio-devices and hormone replacement therapies, these are just a few of the many research areas for which CMAX has provided clinical trial services.

Employing more than 400 staff, CMAX is a 78-bed clinical trials unit, with a database of more than 70,000 clinical trial participants, and utilising state-of-the-art facilities, we are primely positioned, opposite the Royal Adelaide Hospital and part of the Adelaide BioMed City precinct.

About the Role:

Be at the forefront of clinical research and help shape the future of medicine.

CMAX is seeking an exceptional Principal Investigator (PI) to join our expert clinical research team and play a pivotal role in delivering innovative Phase I–II clinical trials, including early-phase and first-in-human research.

This is an opportunity to combine your clinical expertise with your passion for research, providing medical and scientific leadership across a diverse portfolio of studies while helping bring tomorrow’s treatments one step closer to patients.

As a Principal Investigator, you will be responsible for ensuring the highest standards of participant safety, scientific integrity, clinical quality and regulatory compliance, while working alongside sponsors, research teams and a multidisciplinary network of experts.

You’ll be joining a team where clinical excellence meets innovation — and where the work you do can directly contribute to advancing tomorrow’s healthcare.

What You’ll Do:

In this influential medical leadership role, you will:

- Lead the medical oversight of assigned clinical trials from study start-up through to completion;
- Provide expert clinical and scientific leadership across Phase I–II studies;




- Ensure studies are conducted in accordance with GCP, ICH guidelines, protocols and applicable regulatory requirements;
- Provide medical expertise during study design, feasibility assessments and trial planning;
- Conduct participant eligibility assessments, physical examinations and ongoing medical monitoring;
- Make critical clinical and safety decisions, including providing after-hours medical and adverse event support where required;
- Work collaboratively with study sponsors, CROs, vendors, regulators and internal multidisciplinary teams;
- Contribute to staff training, quality improvement initiatives and internal clinical education;
- Support and mentor fellow investigators, sharing your clinical knowledge and research expertise;
- When required, step into a Sub-Investigator (SI) capacity to provide continuity of medical oversight during periods of leave or unavailability of other designated/primary Principal Investigators.

About you:

You are a confident and collaborative medical practitioner with sound clinical judgement, a strong commitment to participant safety and an interest in advancing medical knowledge through high-quality clinical research.

You will bring

- Current AHPRA registration with a minimum of 5 years’ post-registration experience;
- Previous experience working in clinical research in a Principal Investigator or similar senior clinical role;
- Fellowship qualification (preferred, but not essential);
- A recognised medical specialty is advantageous, but not mandatory;
- Current ICH GCP certification;
- Current ALS 1 certification, or a willingness to obtain this;
- Robust clinical judgement, decision-making and communication skills;
- The ability to confidently lead, collaborate and make sound clinical decisions in a fast-paced research environment;
- Professional Indemnity Insurance (may be arranged by CMAX depending on contract type);




- A commitment to completing and actively contributing to our internal CMAX PI School training program.

Why CMAX?

At CMAX, you’ll have the opportunity to work at the cutting edge of clinical research, contributing to studies that have the potential to change the way diseases are treated and healthcare is delivered.

You’ll be part of an experienced and cooperative research environment where your clinical expertise is valued, your decisions make a difference and your contribution can help move promising treatments from the laboratory towards the people who need them.

We offer:

- The opportunity to work at the forefront of creative Phase I–II clinical research;
- Exposure to groundbreaking and early-phase studies that contribute to the development of future treatments;
- The opportunity to work alongside experienced investigators, clinicians and clinical research professionals;
- A collaborative, supportive and highly specialised research environment;
- Competitive remuneration and opportunities for ongoing professional development;
- The opportunity to contribute to CMAX PI School and our broader culture of clinical education and knowledge sharing;
- The chance to be part of an organisation committed to Advancing Tomorrow’s Healthcare;
- Important Location & Employment Requirements.

Please note - This role is suitable only for persons who reside in or relocate to South Australia as it is an onsite hands-on role. Remote or hybrid options are not available for this position. Full time is preferred, however Part-time flexibility may be considered pending availability details for at least 0.8 FTE.

Ready to Make an Impact?

If you are a dedicated clinician with a passion for advancing medical science, we invite you to join our team, please apply by attaching your application letter and CV via the Apply Now function.

Only candidates who have the right to work unrestricted in Australia need apply for this position.

Applications will close on Sunday 18 October 2026.

Please note that we may be conducting interviews during the advertisement period and retain the right to withdraw the advert should we select a successful applicant prior to the closing date.

📌 Principal Investigator (Adelaide)
🏢 CMAX Clinical Research
📍 Adelaide