Job Description

We are seeking a highly motivated Senior Scientist with solid expertise in cell culture, molecular biology, and assay development to support discovery and pre-clinical development of RNA-based therapeutics. This role will contribute to in vitro and in vivo studies, working cross-functionally to evaluate efficacy, mechanism, and PK/PD relationships from early discoveries through candidate selection.

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Key responsibilities

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Design, execute, and analyse cell-based assays to evaluate RNA therapeutic activity and mechanism of action.

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Culture and maintain various cell types, including established cell lines, primary cells, and iPSCs.

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Perform molecular and protein biology techniques, including nucleic acid isolation, qPCR, RT-qPCR, and Western blotting.

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Develop, optimise, and implement new protocols and assays to address key scientific questions.

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Guide and support in vivo efficacy studies and interpret PK/PD relationships.

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Liaise with external collaborators, CROs and service providers, and contribute to animal ethics applications, SOPs and study documentation.

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Analyse data, document experiments, and present results in team meetings and project reviews.

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Keep complete and accurate records in the electronic lab notebook,



and make sure data is stored and archived so it can stand up to later scrutiny.

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Contribute to project strategy through experimental design and troubleshooting.

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Take ownership of key laboratory instruments, including routine maintenance, troubleshooting and training other users.

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Required Qualifications

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PhD (or Masters with substantial relevant experience) in molecular biology, cell biology, biotechnology, or related field.

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Experience with RNA therapeutic development from early discovery through pre-clinical development with strong background in oligonucleotide, siRNA, ASO, mRNA or CRISPR platforms.

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Hands-on experience with in vivo studies in rodent models and a working knowledge of animal ethics requirements.

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A track record of research output, such as peer-reviewed publications or conference presentations.

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Ability to work independently and collaboratively in a fast-paced research environment.

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Strong data analysis, documentation, and communication skills.

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Applicants must have the right to live and work in Australia.

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We may close applications early if we receive enough strong candidates, and only shortlisted applicants will be contacted.

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Unlock job insights

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Hirer responsiveness Salary match Number of applicants

📌 Senior Scientist (New South Wales)
🏢 ProGenis Pharmaceuticals
📍 New South Wales