Job Description

Application Deadline

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31 Dec 2026 2026-12-31 8:00:00 2026-12-31 18:00:00 Europe/Paris

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Post-Doctoral position in cancer immunotherapy, Institut Pasteur, Paris, FranceMobilizing helper CD4+ T cellsfor the activation of anti-tumor immunity in lung cancer. Paris, Mai 2026A 2-year, post-doctoral position is available in the Guermonprez lab at Institut Pasteur Paris ("Dendritic cells and adaptive immunity" Unit, Immunology Department https://research.pasteur.fr/fr/department/immunology/). The Guermonprez lab investigates the role of dendritic cell [...]

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Paris, Mai 2026 A 2-year, post-doctoral position is available in the Guermonprez lab at Institut Pasteur Paris ("Dendritic cells and adaptive immunity" Unit, Immunology Department https://research.pasteur.fr/fr/department/immunology/). The Guermonprez lab investigates the role of dendritic cell subsets in regulating T cell responses and explores novel immunotherapeutic approaches (https://www.guermonprezlab.org).

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There is strong evidence that some populations of CD8+ cells like tissue resident memory‐like (TRMs) or poorly differentiated stem‐like T cells (TSL) are associated with favorable clinical outcomes and improved responses to immune checkpoint blockade immunotherapies. However,



the anti‐tumoral function of CD8+ T cells against lung cancer is severely curtailed by immunesuppressive features of the tumor micro‐environment including the onset of T cell exhaustion associated to chronic TCR signaling.

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The Main Objectives Of This Project Are

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- To analyze the compartment of intra‐tumoral CD4+ T cells and characterize their functionality.
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- To design and evaluate novel immunotherapy interventions targeting CD4+ T cells based on recombinant monoclonal antibodies or mRNA‐containing lipid nanoparticles. The project will be primarily developed in a pre‐clinical murine model of lung adenocarcinoma.
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Candidate profile

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- Project leadership, drive and dynamism.
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- A PhD level, preferably without former postdoctoral experience or other with substantial research experience like engineering/biotech schools e.g..
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- Experience with recombinant antibodies or mRNA‐LNP technologies.
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- A former working experience and training in animal experimentation (mandatory).
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- A solid scientific background in immunology (dendritic cells immunology, T lymphocyte immunology, airway immunology, cancer immunology...).
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- A solid interest in cancer immunology and cancer immunotherapy. Carrer development in academic research will be strongly supported by the laboratory.
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Missions

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The Candidate Is Expected To

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- Design experiments and formalize experimental protocols.
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- Organize and conduct wet bench experiments in pre‐clinical models of cancer involving animal experimentation.
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- Analyze experimental data and keep organized data archives in compliance with local policies.
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- Participate actively to M1/M2 student co‐supervision.
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- Interact and collaborate productively with other researchers within and outside of the team, including bioinformatic engineers.
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- Present data in lab meetings and communicate research outputs in scientific meetings.
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- Participate actively to the production of manuscripts for publication.
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Working environment

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The Guermonprez lab is located on the Institut Pasteur historical campus, in central Paris (75015) and affiliated to the Immunology Department and the Stem cell and developmental biology CNRS UMR3738.

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The Institut Pasteur campus host a unique hub of multi‐disciplinary research.

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Research at the Institut Pasteur is based on 3 key strengths: research conducted at all levels of life, from molecules to individuals and populations; multidisciplinary strategies, focusing on molecular and cellular approaches as well as bioinformatics, biophysics, chemistry and nanotechnologies; unique technological facilities.

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Institut Pasteur is engaged on multiple fronts and its discoveries improve prevention, diagnosis and treatment of infectious diseases, neurodegenerative diseases, and cancers.

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Published on: 29 May 2026

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📌 Post-Doctoral position in cancer immunotherapy, Institut Pasteur, Paris, FranceMobilizing helpe[...] (Cells River)
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