Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in cutting-edge drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Position

You will lead the development of innovative analytical workflows that support and accelerate Nurix's DAC platform, applying your expertise in ADC and/or DAC characterization to solve complex scientific challenges. This is an opportunity to shape analytical strategy for a novel therapeutic platform at the forefront of drug discovery and development.

This is a laboratory role requiring assay design, method development, hands-on execution, and scientific communication to project and platform teams. You will design and execute analytical strategies for high-throughput DAC screening, establish quality criteria that drive conjugate advancement decisions, and partner closely with conjugation chemistry, biology, and bioanalytical teams from early screening through candidate selection.

Responsiblities:

- Design, execute and own the DAC screening characterization platform including DAR, aggregation, protein quantitation,



and define the QC thresholds to advance conjugates for a program

- Present findings to project and platform teams; collaborate with conjugation chemistry, bioanalytical, and cell screening groups to align workflows, coordinate sample flow, and influence conjugate advancement decisions

- Lead and conduct in-depth characterization of antibodies and advanced DACs including positional isomers, glycosylation analysis, peptide mapping, and stability

- Integrate DAR, purity, hydrophobicity, and stability data into unified assessments with QC cutoffs that drive go/no-go decisions; identify structure-quality trends across antibody, linker, and payload variables

Requirements:

- PhD with 4+ years of industry experience in biochemistry, analytical chemistry, or a related discipline

- Expertise in ADC/DAC & antibody characterization from method development to data interpretation

- Expertise with LCMS & HPLC methods for antibody and conjugate analysis, including DAR, SEC, peptide mapping, HIC, and other relevant industry leading methods

- Direct experience characterizing ADCs in an industry setting with working knowledge of conjugation chemistry, DAR heterogeneity, and common quality attributes

- Track record of independently designing experiments, developing analytical methods,



troubleshooting assay and instrument performance, and managing priorities across multiple concurrent programs

- Ability to synthesize complex analytical datasets into actionable scientific conclusions and influence project decisions through clear communication to cross-functional teams

Preferred Qualifications

- Experience with native LCMS, positional isomer analysis, glycan analysis, CE-SDS for expanded conjugate or antibody characterization

- Background in peptide mapping, biophysical binding assays, and thermal stability

- Familiarity with developability assessment, forced degradation, or formulation-support analytics for biologics

- Familiarity & experience with Agilent instrumentation & analytical software (MassHunter, Byos, or equivalent)

Culture & Team Fit:

- Ability to work collaboratively across multiple groups within the organization

- Excellent organization and communication with effective presentation skills

- Self-driven and enthusiastic with proficiencies to deliver in a dynamic environment

- Curious mindset with a willingness and flexibility to learn new skills

- High level of creativity and productivity with strong problem-solving skills

Salary Range: 140K - 161K

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📌 Scientist II, Degrader Antibody Conjugate Characterization (Brisbane)
🏢 Important Company of the Sector
📍 Brisbane