LIMITED EDITION

Summer-proof your collagen. Future-proof your skin.

Save 15% on exclusive new sets built to address the visible signs of collagen loss and UV aging.

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FACE LONGEVITY DEFENSE DUO

4.7

4.7 out of 5

4.7 (760 reviews) (760)

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SAVE 15% Longevity Essentials Trio 4.5

4.5 out of 5

4.5 (949 reviews) (949)

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BODY LONGEVITY DEFENSE DUO

4.7

4.7 out of 5

4.7 (2,295 reviews) (2.2K)

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FULL LONGEVITY DEFENSE SET

4.5

4.5 out of 5

4.5 (1,898 reviews) (1.8K)

OS-01 FACE MOISTURIZER

4.7

4.7 out of 5

4.7 (6,459 reviews) (6.4K)

OS-01 EYE CREAM

4.7

4.7 out of 5

4.7 (1,720 reviews) (1.7K)

HEAD-TO-TOE SKIN HEALTH DUO

4.7

4.7 out of 5

4.7 (7,489 reviews) (7.4K)

FACE, EYE + LIP TRIO

4.5

4.5 out of 5

4.5 (967 reviews) (967)

OS-01 FACE SPF BROAD SPECTRUM SPF 30+ PA+++

4.6

4.6 out of 5

4.6 (1,078 reviews) (1K)

HEAD-TO-TOE SKIN HEALTH TRIO

4.7

4.7 out of 5

4.7 (6,570 reviews) (6.5K)

FACE + LIP DUO

4.7

4.7 out of 5

4.7 (3,673 reviews) (3.6K)

BEST SELLERS SET

4.8

4.8 out of 5

4.8 (5,234 reviews) (5.2K)

PREP Facial Cleanser

4.8

4.8 out of 5

4.8 (1,084 reviews) (1K)

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FULL LONGEVITY DEFENSE SET

4.5

4.5 out of 5

4.5 (1,898 reviews) (1.8K)

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FACE LONGEVITY DEFENSE DUO

4.7

4.7 out of 5

4.7 (760 reviews) (760)

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SAVE 15% Longevity Essentials Trio 4.5

4.5 out of 5

4.5 (949 reviews) (949)

OS-01 BODY MOISTURIZER

4.7

4.7 out of 5

4.7 (3,662 reviews) (3.6K)

HEAD-TO-TOE SKIN HEALTH TRIO

4.7

4.7 out of 5

4.7 (6,570 reviews) (6.5K)

OS-01 BODY SPF BROAD SPECTRUM SPF 30 PA+++

4.6

4.6 out of 5

4.6 (134 reviews) (134)

HEAD-TO-TOE SKIN HEALTH DUO

4.7

4.7 out of 5

4.7 (7,489 reviews) (7.4K)

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BODY LONGEVITY DEFENSE DUO

4.7

4.7 out of 5

4.7 (2,295 reviews) (2.2K)

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FULL LONGEVITY DEFENSE SET

4.5

4.5 out of 5

4.5 (1,898 reviews) (1.8K)

BEST SELLERS SET

4.8

4.8 out of 5

4.8 (5,234 reviews) (5.2K)

HEAD-TO-TOE SKIN HEALTH TRIO

4.7

4.7 out of 5

4.7 (6,570 reviews) (6.5K)

COMPLETE SKIN LONGEVITY REGIMEN

4.7

4.7 out of 5

4.7 (10,927 reviews) (10.9K)

HEAD-TO-TOE SKIN HEALTH DUO

4.7

4.7 out of 5

4.7 (7,489 reviews) (7.4K)

DAY + NIGHT LIP DUO

4.6

4.6 out of 5

4.6 (916 reviews) (916)

FACE + LIP DUO

4.7

4.7 out of 5

4.7 (3,673 reviews) (3.6K)

FACE, EYE + LIP TRIO

4.5

4.5 out of 5





4.5 (967 reviews) (967)

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SAVE 15%

FACE LONGEVITY DEFENSE DUO

4.7

4.7 out of 5

4.7 (760 reviews) (760)

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SAVE 15%

BODY LONGEVITY DEFENSE DUO

4.7

4.7 out of 5

4.7 (2,295 reviews) (2.2K)

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SAVE 15%

FULL LONGEVITY DEFENSE SET

4.5

4.5 out of 5

4.5 (1,898 reviews) (1.8K)

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SAVE 15% Longevity Essentials Trio 4.5

4.5 out of 5

4.5 (949 reviews) (949)

OUR APPROACH

Led by science, not hype

See how

Rigorous R&D; platform

End-to-end product development run by our in-house team of scientists.

Scientifically validated claims

Quantified by our proprietary MolClock and Skin Age Modeling methods.

Ongoing clinical studies

Conducted by independent, third-party research organizations.

Peer-reviewed publications The gold standard for scientific research and in skin care.

OUR APPROACH The real proof? It’s in the numbers.

9

years of research

900

peptides screened

22

patents & publications

12000

5-Star Reviews

OUR BREAKTHROUGH PEPTIDE

OS-01: the new standard in peptide technology

Think of OS-01 as a reset button for your skin, helping transparent away the senescent cells that cause wrinkles, hyperpigmentation, and crepiness. As the first peptide scientifically proven to reduce cellular senescence in the skin, OS-01 does what other peptides can’t. 01

Discover the science

6 visible signs of senescence

Lines and wrinkles

Caused by a decline in collagen and elastin production.

Loss of elasticity

Decreased elastin also contributes to lack of firmness.

Uneven skin tone

Irregular melanin production leads to hyperpigmentation.

Rough texture

Compromised skin cell renewal leaves a dry, uneven surface.

Loss of volume

Linked to a decrease in hyaluronic acid, collagen, and elastin.

Thinning skin

Slower cell turnover contributes to a weakened skin barrier.

Daily Essentials The 5-minute skin health routine

Shop all products

PREP Cleanser

OS-01 EYE

OS-01 FACE

OS-01 FACE SPF

Gently cleanse and exfoliate without irritation

PREP Cleanser

Support delicate skin with the highest concentration of OS-01

OS-01 EYE A daily longevity serum and lightweight moisturizer in one

OS-01 FACE

Repair UV aging while protecting against new UV-damage01

OS-01 FACE SPF

Explore our peer-reviewed research

Check out the data The brains behind the breakthrough

Meet the founders The Reference Lab browse articles

- SKIN CARE

Not All Peptides Are Created Equal
- ONESKIN PRODUCTS

Behind the Seal:



How OneSkin Achieved the National Eczema Association's Seal of Acceptance
- LONGEVITY

Skin Care is Health Care: Why Skin Care is the Key to Longevity
- INGREDIENTS

Peptides Vs Growth Factors: Which is Better For Skin Longevity?

Frequently Asked Questions

Peptides are short chains of amino acids. They represent a broad class of molecules with many jobs, from forming the building blocks of larger proteins to acting as cellular messengers. Peptides found naturally in the body (called endogenous peptides), play a crucial role in tissue growth, hormone regulation, and other biological processes.

Exogenous peptides, which can be injected, ingested or delivered topically like OS-01, can send out signals to skin cells to trigger collagen and hyaluronic acid production, aid in cellular repair, and help strengthen the skin barrier.01,02,03

OS-01 reduces the accumulation of senescent cells. These cells release inflammatory chemicals that cause neighboring cells to become dysfunctional, kicking off a domino effect in skin and accelerating skin aging. By reducing this inflammatory response, OS-01 helps prevent the accumulation of senescent cells in skin, improving key skin aging biomarkers and keeping other skin cells healthy and thriving.01,02,03

OneSkin is for everyone. Whether you’re taking a preventative approach or want your skin’s health and appearance to reflect how you feel on the inside, our scientifically proven products work at the cellular level to keep your skin looking, feeling, and acting younger and healthier as you age.01,02,03

Through lab studies and clinical studies, our products have been shown to combat the visible and invisible signs of aging, from collagen loss and thinning skin to a compromised barrier function.01,02,03

To learn more about the specific benefits of each product, visit oneskin.co/claims.

With daily use, you can expect to see visible results within 12 weeks, though some people see changes even sooner. This time frame allows OS-01 to work at the cellular level, improving the long-term health and appearance of your skin.01,02,04

01 Zonari, A., et al. Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models. npj Aging, 9(1), 1-15. 2023. doi:10.1038/s41514-023-00109-1

02 Zonari A., et al. Double-blind, vehicle-controlled clinical investigation of peptide OS-01 for skin rejuvenation. J Cosmet Dermatol. 2024; 23: 2135-2144. doi:10.1111/jocd.16242

03 Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin or hair cells in the OneSkin lab. Explore more at oneskin.co/claims

04 Zonari, A., et al. Clinical efficacy of OS-01 peptide formulation in reducing the signs of periorbital skin aging. Int J Cosmet Sci . 2025; 00: 1–11. doi:10.1111/ics.13042

PHILANTHROPY

Propelled by a shared mission to change the way humans experience aging

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We donate a portion of sales to the Aging Forward (formerly Shepherd's Center of America), which provides enriching opportunities for lifelong learning, volunteer service, healthy living, and community connections - all of the things that give life meaning.

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