Research Associate II/III - Bioanalytical / In Vitro ADME / DMPK at NurixAbout the role Nurix Therapeutics is seeking a highly motivated and detail-oriented Research Associate to join our Bioanalytical-In Vitro DMPK team.
This position plays a critical role in supporting our drug discovery pipeline by providing bioanalytical support for pharmacokinetics (PK) and non-GLP safety toxicology studies.
The successful candidate will be responsible for developing, qualifying, and executing bioanalytical methods to analyze small molecules, metabolites, and biomarkers in various biological matrices.
They will also be involved in conducting in vitro stability assays, metabolic identification, and sample analysis, ensuring data accuracy and compliance with regulatory standards.
This role offers an excellent opportunity to work in a collaborative environment with a focus on innovative drug development, utilizing advanced analytical techniques to characterize ADME properties of drug candidates.Key factsLocation: Brisbane, CA Engagement: Full-time, onsiteWhat you'll doProvide comprehensive bioanalytical support for pharmacokinetic (PK) studies, including sample analysis and data interpretation, to support drug discovery and development projects.Develop, optimize, and qualify sensitive and specific LC-MS/MS methods for quantifying small molecules, metabolites, and biomarkers in biological matrices such as plasma, tissue, and other biological fluids.Independently operate, troubleshoot, and maintain LC-MS/MS systems, including AB SCIEX instruments, to ensure high-quality data generation and instrument performance.Conduct in vitro stability assays to evaluate drug metabolism, including plasma stability, microsomal stability, and other relevant assays, to inform ADME profiling.Perform metabolic identification studies using LC-QTOF MS/MS, including mass analysis, biotransformation pathway elucidation, and metabolite profiling.Collaborate closely with cross-functional teams, including medicinal chemistry, pharmacology, and toxicology, to meet project goals and provide bioanalytical insights.Manage outsourced bioanalytical projects with Contract Research Organizations (CROs), overseeing sample analysis, data quality, and timely delivery of results.Maintain detailed,



accurate, and compliant electronic laboratory notebooks (ELNs) documenting all experimental procedures, data, and observations.Support method transfer, validation, and troubleshooting activities to ensure robustness and reproducibility of bioanalytical assays.Adhere strictly to company policies, safety protocols, and regulatory guidelines, including GLP and non-GLP standards, to ensure data integrity and compliance.Participate in team meetings, contribute to scientific discussions, and assist in preparing technical reports, summaries, and presentations for internal and external stakeholders.Stay current with advancements in bioanalytical techniques, mass spectrometry, and ADME methodologies to continuously improve laboratory practices and data quality.RequirementsBachelor's or Master's degree in Chemistry, Biochemistry, Pharmaceutical Sciences, or related field, with over 4 years of experience in a discovery or early development environment utilizing LC-MS/MS.Proven expertise in developing, optimizing, and qualifying bioanalytical assays for small molecules in biological matrices using LC-MS/MS technology.Extensive hands-on experience with AB SCIEX mass spectrometry software, including method setup, troubleshooting, and data analysis.Strong understanding of pharmacokinetics, ADME principles, and in vitro stability assays.Demonstrated ability to independently operate and troubleshoot LC-MS/MS instrumentation, including maintenance and calibration.Experience in performing metabolic identification studies using LC-QTOF MS/MS, including biotransformation pathway analysis.Excellent organizational skills with the ability to manage multiple projects and prioritize tasks effectively.Strong written and verbal communication skills,



capable of preparing detailed technical reports and collaborating with multidisciplinary teams.Knowledge of laboratory safety procedures, GLP regulations, and data integrity standards.Ability to work independently and as part of a team, demonstrating flexibility and problem-solving skills.Familiarity with data management systems such as Phoenix or similar PK data analysis software is preferred.Nice to haveExperience with high/ultra-performance liquid chromatography (H/UPLC) techniques and associated instrumentation.Prior management experience working with CROs on bioanalytical projects, including oversight and quality control.Knowledge of additional analytical techniques such as HPLC, NMR, or other relevant methods.Familiarity with regulatory submissions and compliance requirements related to bioanalytical data.Ability to troubleshoot complex scientific equipment and develop innovative solutions for analytical challenges.Strong interpersonal skills, with the ability to communicate effectively across teams and with external partners.Skills & toolsLC-MS/MS (liquid chromatography-tandem mass spectrometry)LC-QTOF MS/MS (liquid chromatography-quadrupole time-of-flight mass spectrometry)Bioanalytical method development and validationSample analysis in biological matrices such as plasma, tissue, and other fluidsData analysis and management software, including Phoenix or similar PK data softwareLaboratory troubleshooting and maintenance of analytical instrumentsKnowledge of ADME and pharmacokinetic principlesPractical notesNurix is an Equal Opportunity Employer committed to fostering a diverse and inclusive workplace.
We offer a competitive salary and comprehensive benefits package.
Candidates must be legally authorized to work in the United States.Salary ranges are as follows: RA II: $92,891 - $106,507 RA III: $110,101 - $124,079Nurix encourages applicants from all backgrounds to apply and values the contributions of a diverse team.
Candidates should be prepared to demonstrate their experience and skills through interviews and technical assessments.The position requires in office presence at our Brisbane, CA location, with no remote work options.
All applicants must adhere to company policies regarding confidentiality, safety, and regulatory compliance.
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📌 Research Associate Ii/Iii– Bioanalytical/In Vitro Adme/Dmpk (Brisbane)
🏢 Nurix
📍 Brisbane