Operating Principal, Origination (Director or Senior Director level equivalent) at Flagship Pioneering, Inc.

About the role

Flagship Pioneering, Inc. is seeking an Operating Principal to play a crucial role in the initiation and expansion of our NewCos. This position involves overseeing operational strategies and initiatives across various companies, working in close collaboration with scientific leaders to convert innovative ideas into successful outcomes. The ideal candidate will have a strong background in biotech or life sciences and a proven ability to lead teams effectively.

Key facts

- Location: Cambridge, MA USA
- Engagement: Full-time

What you'll do

- Lead the strategic and operational planning processes for one or more NewCos, ensuring alignment with overall business goals.
- Drive corporate development initiatives, which include forming partnerships, securing funding, and creating strategic alliances, while actively engaging with the Board of Directors and other key stakeholders.
- Work closely with scientists and executive teams to ensure that technical advancements are in sync with operational objectives and market needs.
- Recruit, mentor, and guide high-performing teams across various functional areas to foster a culture of excellence and innovation.
- Collaborate with Flagship's central teams, including Finance, Talent Acquisition, Legal/IP, and HR, to establish robust operational frameworks for each NewCo.
- Formulate and implement operational and long-term strategic plans, ensuring that all milestones are achieved within budgetary constraints and timelines.
- Build and maintain strong relationships with external stakeholders, including investors, partners, and influential leaders in the biotech sector.
- Analyze market trends and competitive landscapes to inform strategic decisions and operational improvements.
- Facilitate cross-functional collaboration to enhance project execution and drive company performance.
- Monitor and evaluate the performance of NewCos, providing insights and recommendations for continuous improvement.




- Represent the company at industry events and conferences to enhance visibility and foster networking opportunities.
- Champion a culture of innovation and accountability within the organization, inspiring teams to pursue excellence.

Requirements

- An advanced degree (MS or PhD) in Chemistry, Biology, Physics, or a related field is required.
- A minimum of 10 years of experience in the biotech, pharmaceutical, or life sciences sectors, focusing on strategy, operations, or program management.
- Experience in management consulting is a plus, providing a strong foundation for strategic thinking.
- A proven track record of leadership in strategic, operational, or corporate development roles, particularly in early-stage biotech companies.
- Strong scientific acumen with the ability to quickly grasp new scientific developments and translate them into actionable strategies.
- Demonstrated success in building and leading high-performing teams, fostering a collaborative and results-oriented environment.
- Exceptional communication skills, with the ability to influence and motivate diverse stakeholders, including investors and internal teams.
- Strong analytical and problem-solving skills, capable of navigating complex challenges and developing effective solutions.
- An entrepreneurial mindset, characterized by resilience and a proactive approach to driving initiatives forward.

Nice to have

- Experience with fundraising and investor relations in the biotech sector.
- Familiarity with regulatory processes and compliance in the life sciences industry.
- A network of contacts within the biotech and life sciences communities.
- Previous experience in a startup setting,



demonstrating adaptability and resourcefulness.
- Knowledge of digital health technologies and their applications in healthcare.

Skills & tools

- In-depth knowledge of the biotech and life sciences industries.
- Expertise in operational strategy development and team leadership.
- Strong interpersonal skills, enabling effective collaboration and communication across diverse teams.

Practical notes

- Please note that visa sponsorship is not available for this position.
- Flagship Pioneering offers a competitive salary range of $220,000 to $269,500, with total compensation dependent on various factors, including qualifications and experience.
- healthcare coverage
- annual incentive program
- retirement plans
- additional perks designed to support employee well-being.

At Flagship Pioneering, we are committed to inventing and building platform companies that aim to transform human health and sustainability.

Since our founding in 2000, we have established over 100 companies addressing significant global challenges, including health crises and agricultural sustainability.

We value diversity and inclusivity in our workplace and encourage applicants from all backgrounds to apply, even if they do not meet every qualification listed.

We believe that diverse perspectives enhance our mission, and we look forward to learning about your experiences and interest in joining our team.

Flagship Pioneering is an equal opportunity employer.

All qualified candidates will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law.

Please be aware that we do not accept unsolicited resumes from recruitment or staffing agencies unless directly contacted by our internal Talent Acquisition team.

Any unsolicited submissions will become the property of Flagship Pioneering, and we will not be liable for any referral or other fees.

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📌 Operating Principal, Origination (Director or Senior Director level equivalent) (Cambridge)
🏢 Flagship Pioneering
📍 Cambridge