Senior Scientist, Conjugation Biochemistry

About the role We are seeking an experienced Senior Scientist to spearhead our conjugation biochemistry efforts at Flagship Pioneering, Inc. The successful candidate will be a proactive and independent researcher, committed to generating high-quality data within a fast-paced research setting. This position will involve supporting a variety of bioconjugation projects that span multiple research and development areas.

Key facts

Location: Cambridge, MA, USA

Engagement: Full-time

Team: Conjugation Biochemistry Team

What you'll do

- Design, synthesize, and analyze oligonucleotide-conjugates that are linked to antibodies and other platforms, refining conjugation protocols through both established and novel chemical methodologies as part of our assay development process.
- Work closely with the assay development team to improve conjugates that align with our ongoing projects.
- Participate in a cross-functional team to ensure adherence to project timelines, providing consistent updates and effectively communicating progress to all stakeholders.
- Establish and nurture strong collaborative relationships with key partners within the organization to facilitate research and development efforts aimed at advancing pre-clinical initiatives.
- Assist in the preparation of research documentation and presentations for internal teams, executive leadership, and external partners.
- Maintain meticulous and organized laboratory notebooks and batch records to ensure compliance and reproducibility of experiments.
- Conduct analytical characterization of conjugates, employing purification techniques such as RP-HPLC, FPLC, SEC, and IEX.
- Mentor junior scientists and provide guidance on best practices in bioconjugation and analytical methods.




- Stay current with advancements in bioconjugation technologies and methodologies, integrating new techniques into ongoing projects as appropriate.
- Contribute to the development of standard operating procedures (SOPs) for bioconjugation processes, ensuring consistency and quality across projects.
- Engage in troubleshooting and problem-solving activities to address experimental challenges and optimize workflows.

Requirements

- A Ph.D. in Biochemistry, Chemistry, or a closely related discipline.
- A minimum of 5 years of relevant industry experience in bioconjugation, particularly in the design, synthesis, and validation of oligonucleotide conjugates.
- Strong understanding of project timelines and deliverables, with the ability to coordinate efforts among diverse stakeholders.
- Exceptional analytical and problem-solving abilities, with a proactive mindset towards exploring and implementing new methodologies.
- Excellent written and verbal communication skills, capable of conveying complex scientific concepts to varied audiences.
- Hands-on experience with modern bioconjugation techniques involving antibodies, proteins, peptides, and other biomolecules.
- Proven expertise in the analytical characterization of conjugates, with proficiency in purification techniques including RP-HPLC, FPLC, SEC, and IEX.
- Ability to work independently or collaboratively within a team, requiring minimal supervision.
- Adaptable and adaptable,



capable of managing shifting priorities and challenges with professionalism in a dynamic environment.
- Self-motivated with strong interpersonal, organizational, and communication skills, taking an active role in a collaborative setting.

Nice to have

- Experience with high-throughput screening methods for bioconjugate evaluation.
- Familiarity with regulatory requirements and compliance in biopharmaceutical development.
- Background in immunology or related fields that enhance bioconjugation applications.
- Knowledge of bioinformatics tools for data analysis and interpretation.

Skills & tools

- Proficient in bioconjugation techniques and analytical methodologies relevant to biochemistry.
- Familiarity with laboratory data analysis software and tools specific to bioconjugation research.

Practical notes

- Please note that visa sponsorship is not available for this position.
- The salary for this role ranges from $126,000 to $181,500, depending on the candidate's qualifications, skills, and experience.

Benefits

- Flagship Labs 103 offers comprehensive healthcare coverage, an annual incentive program, retirement benefits, and a range of additional perks.

Compensation details are based on estimates at the time of posting and may be subject to change.

Equal opportunity employment

Flagship Pioneering is committed to equal opportunity employment, encouraging applicants from all backgrounds, including race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity, or veteran status.

We invite candidates with diverse experiences to apply, even if they do not meet every specified qualification.

#J-18808-Ljbffr

📌 Senior Scientist, Conjugation Biochemistry (Cambridge)
🏢 Flagship Pioneering
📍 Cambridge