Application Deadline 31 Dec 2026 2026-12-31 8:00:00 2026-12-31 18:00:00 Europe/Paris Post-Doctoral position in cancer immunotherapy, Institut Pasteur, Paris, FranceMobilizing helper CD4+ T cellsfor the activation of anti-tumor immunity in lung cancer. Paris, Mai 2026A 2-year, post-doctoral position is available in the Guermonprez lab at Institut Pasteur Paris (“Dendritic cells and adaptive immunity” Unit, Immunology Department https://research.pasteur.fr/fr/department/immunology/). The Guermonprez lab investigates the role of dendritic cell […] "25-28 rue du Dr.

Roux, 75015, Paris" Pierre Guermonprez [email protected] Add to Calendar iCalendar

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Paris, Mai 2026 A 2-year, post-doctoral position is available in the Guermonprez lab at Institut Pasteur Paris (“Dendritic cells and adaptive immunity” Unit, Immunology Department https://research.pasteur.fr/fr/department/immunology/). The Guermonprez lab investigates the role of dendritic cell subsets in regulating T cell responses and explores novel immunotherapeutic approaches (https://www.guermonprezlab.org). There is robust evidence that some populations of CD8+ cells like tissue resident memory-like (TRMs) or poorly differentiated stem-like T cells (TSL) are associated with favorable clinical outcomes and improved responses to immune checkpoint blockade immunotherapies.

However, the anti-tumoral function of CD8+ T cells against lung cancer is severely curtailed by immunesuppressive features of the tumor micro-environment including the onset of T cell exhaustion associated to chronic TCR signaling.



CD4+ T cell help can potentially reactivate the generation of anti-tumor CD8+ effectors but this response is somehow impaired.

The Main Objectives Of This Project

Are To analyze the compartment of intra-tumoral CD4+ T cells and characterize their functionality.

To design and evaluate novel immunotherapy interventions targeting CD4+ T cells based on recombinant monoclonal antibodies or mRNA-containing lipid nanoparticles. The project will be primarily developed in a pre-clinical murine model of lung adenocarcinoma. Candidate profile We are looking for highly motivated individuals willing to bring new insights into the biology of adaptive immunity against cancer and spark innovation in cancer immunotherapy in pre-clinical settings.

The successful candidate is expected to have: Project leadership, drive and dynamism.

A PhD level, preferably without former postdoctoral experience or other with substantial research experience like engineering/biotech schools e.g..

Experience with recombinant antibodies or mRNA-LNP technologies.

A former working experience and training in animal experimentation (mandatory).

A solid scientific background in immunology (dendritic cells immunology, T lymphocyte immunology, airway immunology, cancer immunology…).

A strong interest in cancer immunology and cancer immunotherapy.



Carrer development in academic research will be strongly supported by the laboratory.

Missions The Candidate Is Expected To Design experiments and formalize experimental protocols.

Organize and conduct wet bench experiments in pre-clinical models of cancer involving animal experimentation.

Analyze experimental data and keep organized data archives in compliance with local policies.

Participate actively to M1/M2 student co-supervision.

Interact and collaborate productively with other researchers within and outside of the team, including bioinformatic engineers.

Present data in lab meetings and communicate research outputs in scientific meetings.

Participate actively to the production of manuscripts for publication. Working environment The Guermonprez lab is located on the Institut Pasteur historical campus, in central Paris (75015) and affiliated to the Immunology Department and the Stem cell and developmental biology CNRS UMR3738.

The Institut

Pasteur campus host a unique hub of multi-disciplinary research. Research at the Institut Pasteur is based on 3 key strengths: research conducted at all levels of life, from molecules to individuals and populations; multidisciplinary strategies, focusing on molecular and cellular approaches as well as bioinformatics, biophysics, chemistry and nanotechnologies; unique technological facilities.

Institut

Pasteur is engaged on multiple fronts and its discoveries improve prevention, diagnosis and treatment of infectious diseases, neurodegenerative diseases, and cancers. Contact & applications For applications, please send to [email protected] one CV, a publication list, the email contact for 2 references.

Published on: 29 May 2026

📌 Post-Doctoral position in cancer immunotherapy, Institut Pasteur, Paris, FranceMobilizing helper+ T cellsfor the activation of anti-tumor immunity in lung cancer. (Cells River)
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📍 Cells River