Senior Scientist, LNP Process and Development at Flagship Pioneering, Inc. About the role We are seeking a highly motivated and experienced Senior Scientist to join our team focused on the development and scaling of lipid nanoparticle (LNP) formulations for nucleic acid delivery. This position will involve working closely with cross-functional teams to optimize formulation parameters, improve manufacturing processes, and ensure the successful translation of LNP technologies from laboratory to production scale. The ideal candidate will have a strong background in nanoparticle formulation, process development, and experience working with nucleic acid-based therapeutics such as mRNA and DNA. The role offers an exciting opportunity to contribute to innovative projects in a quick-paced, cooperative environment dedicated to advancing cutting-edge therapies.

Key facts
Location: Cambridge, MA, USA
Engagement: Full-time
Team: Not specified

What you'll do

- Lead efforts to develop and optimize LNP formulations, focusing on critical parameters such as mixing conditions, lipid composition, encapsulation efficiency, and particle stability.
- Design and execute experiments to enhance the performance, stability, and manufacturability of LNPs containing modified DNA and cofactor mRNA.
- Collaborate with internal teams including formulation scientists, process engineers, and analytical groups to characterize LNPs and troubleshoot formulation challenges.
- Support scale-up activities by translating laboratory processes into scalable manufacturing protocols, ensuring consistency and reproducibility.
- Assist in the transfer of processes from research to manufacturing, working closely with external vendors or internal production teams to facilitate technology transfer.
- Analyze experimental data, interpret results, and prepare detailed reports to inform decision-making and further development efforts.
- Stay current with advances in LNP technology, nucleic acid delivery systems, and related fields to incorporate best practices into ongoing projects.




- Contribute to the development of process validation protocols, stability testing, and quality control strategies for LNP formulations.
- Participate in cross-disciplinary project meetings to align formulation strategies with overall project timelines and objectives.
- Troubleshoot formulation and process issues, providing technical guidance to team members and external partners.
- Assist in preparing documentation for regulatory submissions or internal quality audits related to LNP manufacturing processes.

Requirements

- A PhD in Chemical Engineering, Pharmaceutical Sciences, Bioengineering, or a related discipline, with a minimum of 3 years of relevant industry experience; or an M.S. with at least 8 years of experience; or a Bachelor's degree with 10 years of relevant experience.
- Demonstrated expertise in process development, scale-up, or manufacturing of nanoparticle or LNP systems.
- Prior experience working with nucleic acid formulations, especially mRNA or DNA, is highly desirable.
- Strong understanding of formulation techniques such as T mixing or similar scalable methods, along with proficiency in characterization techniques like dynamic light scattering (DLS), encapsulation efficiency assays, and stability testing.
- Proven ability to design experiments, analyze complex data sets, and troubleshoot technical challenges effectively.
- Excellent communication skills, with the ability to clearly present technical information to multidisciplinary teams.
- Ability to work independently and collaboratively in a fast-paced environment, managing multiple priorities.
- Strong problem-solving skills, attention to detail, and a proactive approach to project challenges.




- Knowledge of regulatory considerations related to nanoparticle formulations and biologics is a plus.

Nice to have

- Experience with formulation screening, high-throughput optimization, and development of next-generation LNP systems.
- Familiarity with Good Manufacturing Practice (GMP) processes and documentation requirements.
- Prior experience working in a biotech or pharmaceutical manufacturing setting, especially with scale-up and process validation.
- Knowledge of stability testing protocols and regulatory compliance standards for biologics and nanoparticle-based therapeutics.

Skills & tools

- Expertise in experimental design, data analysis, and troubleshooting within a laboratory or manufacturing environment.
- Familiarity with LNP characterization techniques, including DLS, electron microscopy, and encapsulation assays.
- Proficiency with laboratory instrumentation related to nanoparticle analysis and formulation.
- Ability to interpret complex data and translate findings into actionable process improvements.
- Strong organizational skills to manage multiple experiments and documentation requirements.

Practical notes

- The salary range for this position is $100,000 - $143,000. Compensation will be determined based on the candidate's qualifications, experience, and skills.
- Flagship Pioneering offers a comprehensive benefits package, including healthcare coverage, an annual incentive program, retirement plans, and other employee benefits.
- This role is based on-site in Cambridge, MA, and involves working at the company's physical location; remote or hybrid work arrangements are not specified.
- Applications should be submitted promptly, as the position may close once a suitable candidate is hired.
- Flagship Pioneering is committed to fostering diversity and inclusion and is an equal opportunity employer. All qualified applicants will receive consideration without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, veteran status, or any other protected characteristic.

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📌 Senior Scientist, LNP Process and Development (Cambridge)
🏢 Flagship Pioneering
📍 Cambridge